|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans).
|
20736317 |
2010 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Two susceptibility loci identified for prostate cancer aggressiveness.
|
25939597 |
2015 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This study demonstrated a significant association between the MSMB rs10993994 polymorphisms and PCa risk.
|
31773691 |
2019 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These data indicate that the increase in PC risk associated with rs10993994:C>T is likely mediated by the variant's effect on PSP94 expression; however, this effect does not extend to NCOA4 in the data presented here.
|
22887727 |
2013 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The observations that rs10993994 is the strongest associated variant in the region and its risk allele has a major effect on the transcriptional activity of MSMB, a gene with previously described prostate cancer suppressor function, together suggest the T allele of rs10993994 as a potential causal variant at 10q11 that confers increased risk of prostate cancer.
|
19153072 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs10993994 genotype in the MSMB gene modifies the association between number of sexual partners and PCa risk.
|
24037734 |
2013 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.
|
20967219 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant.
|
19997100 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Six markers associated with early-onset prostate cancer [rs2171492 (7q32), rs6983561 (8q24), rs10993994 (10q11), rs4430796 (17q12), rs1799950 (17q21), and rs266849 (19q13)] were genotyped.
|
22144497 |
2012 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Rs11672691 and rs10993994 were associated with both fatal and nonfatal PCa, while rs6465657, rs7127900, rs2735839, and rs13385191 were associated with nonfatal PCa only.
|
24411283 |
2014 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Regardless of race and ethnicity or rs10993994 genotype, men with low blood levels of MSP have increased risk of prostate cancer.
|
23213189 |
2013 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recent functional work has shown that different alleles of the significantly associated SNP in the promoter of MSMB found to be associated with prostate cancer risk, rs10993994, can influence its expression in tumors and in vitro studies.
|
19644707 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
PCa susceptibility was associated with TT genotype of SNP rs10993994 in this cohort of Scottish men and the increased risk of PCa was modified by serum enterolactone concentrations.
|
22733159 |
2012 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found.
|
30774776 |
2019 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results suggest a mechanism by which rs10993994 might predispose to prostate cancer and raise the possibility that genetic variation might need to be considered in interpreting the levels of these biomarkers.
|
20696662 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our data indicated that MSMB gene rs10993994 polymorphism was associated with an increased risk of PC.
|
28212531 |
2017 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.
|
20717903 |
2011 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
|
26443449 |
2015 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, in a small case-control study of prostate cancer cases from Utah high-risk pedigrees, we have significantly replicated association of prostate cancer with rs10993994</span> (10q11) upon study-wide correction for multiple comparisons.
|
19336566 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, loci associated with risk for prostate cancer, such as rs7920517 and rs10993994, might also be used to predict the recurrence of prostate-specific antigen in prostate cancer patients receiving radical prostatectomy.
|
19900942 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
|
20676098 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk.
|
21085629 |
2010 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association scan for variants associated with early-onset prostate cancer.
|
24740154 |
2014 |